00000 - Document - Template Link link:presentationLink link:calculationLink link:definitionLink 100000 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 100010 - Statement - Consolidated Balance Sheets (Unaudited) link:calculationLink link:presentationLink link:definitionLink 100020 - Statement - Consolidated Balance Sheets (Unaudited) (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 100030 - Statement - Consolidated Statements of Operations (Unaudited) link:calculationLink link:presentationLink link:definitionLink 100040 - Statement - Consolidated Statements of Cash Flows (Unaudited) link:calculationLink link:presentationLink link:definitionLink 100050 - Disclosure - Nature of Business link:calculationLink link:presentationLink link:definitionLink 100060 - Disclosure - Summary of Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 100070 - Disclosure - Merger with Mirna Therapeutics link:calculationLink link:presentationLink link:definitionLink 100080 - Disclosure - Fair Value of Financial Instruments link:calculationLink link:presentationLink link:definitionLink 100090 - Disclosure - Available-for-Sale Investments link:calculationLink link:presentationLink link:definitionLink 100100 - Disclosure - Property and Equipment, Net link:calculationLink link:presentationLink link:definitionLink 100110 - Disclosure - Accrued Expenses link:calculationLink link:presentationLink link:definitionLink 100120 - Disclosure - Common Stock link:calculationLink link:presentationLink link:definitionLink 100130 - Disclosure - Preferred Stock link:calculationLink link:presentationLink link:definitionLink 100140 - Disclosure - Preferred Units link:calculationLink link:presentationLink link:definitionLink 100150 - Disclosure - Equity-based Compensation and Equity Incentive Plans link:calculationLink link:presentationLink link:definitionLink 100160 - Disclosure - AbbVie Collaboration Agreement link:calculationLink link:presentationLink link:definitionLink 100170 - Disclosure - Net Loss per Share link:calculationLink link:presentationLink link:definitionLink 100180 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 100190 - Disclosure - Summary of Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 100200 - Disclosure - Fair Value of Financial Instruments (Tables) link:calculationLink link:presentationLink link:definitionLink 100210 - Disclosure - Available-for-Sale Investments (Tables) link:calculationLink link:presentationLink link:definitionLink 100220 - Disclosure - Property and Equipment, Net (Tables) link:calculationLink link:presentationLink link:definitionLink 100230 - Disclosure - Accrued Expenses (Tables) link:calculationLink link:presentationLink link:definitionLink 100240 - Disclosure - Equity-based Compensation and Equity Incentive Plans (Tables) link:calculationLink link:presentationLink link:definitionLink 100250 - Disclosure - Net Loss per Share (Tables) link:calculationLink link:presentationLink link:definitionLink 100260 - Disclosure - Nature of Business - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100270 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100280 - Disclosure - Merger with Mirna Therapeutics - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100290 - Disclosure - Fair Value of Financial Instruments - Schedule of Company's Classified Assets Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 100300 - Disclosure - Available-for-Sale Securities - Summary of Available-for-Sale Securities Held (Detail) link:calculationLink link:presentationLink link:definitionLink 100310 - Disclosure - Available-for-Sale Securities - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100320 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) link:calculationLink link:presentationLink link:definitionLink 100330 - Disclosure - Property and Equipment, Net - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100340 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 100350 - Disclosure - Accrued Expenses - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100360 - Disclosure - Common Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100370 - Disclosure - Preferred Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100380 - Disclosure - Equity-based Compensation and Equity Incentive Plans - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100390 - Disclosure - Equity-based Compensation and Equity Incentive Plans - Schedule of Stock Option Activity Under 2015 and 2017 Plan (Detail) link:calculationLink link:presentationLink link:definitionLink 100400 - Disclosure - Equity-based Compensation and Equity Incentive Plans - Schedule of Stock Option Activity Under 2015 and 2017 Plan (Parenthetical) (Detail) link:calculationLink link:presentationLink link:definitionLink 100410 - Disclosure - Equity-based Compensation and Equity Incentive Plans - Schedule of Restricted Stock Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100420 - Disclosure - Equity-based Compensation and Equity Incentive Plans - Schedule of Equity-based Compensation Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 100430 - Disclosure - Equity-based Compensation and Equity Incentive Plans - Schedule of Equity-based Compensation Expenses by Award Type (Detail) link:calculationLink link:presentationLink link:definitionLink 100440 - Disclosure - AbbVie Collaboration Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100450 - Disclosure - Net Loss per Share - Schedule of Potentially Common Shares Excluded from Calculation of Net Loss Per share (Detail) link:calculationLink link:presentationLink link:definitionLink