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Cover
Document and Entity Information
Financial Statements
Condensed Balance Sheets
Condensed Balance Sheets (Parenthetical)
Condensed Statements of Operations and Comprehensive Loss
Statements of Stockholder's Equity (Deficit)
Statements of Stockholder's Equity (Deficit) (Parenthetical)
Condensed Statements of Cash Flows
Notes to Financial Statements
Nature of Business and Basis of Presentation
Summary of Significant Accounting Policies
Marketable Securities
Fair Value Measurements
Property and Equipment
Accrued expenses
Common Stock
Stock Option Plans
Restructuring Charges
Income Taxes
Shared Services Agreement with Asuragen
Retirement Plan
License Agreements
Commitments and Contingencies
Net Loss Per Share Attributable to Common Stockholders
Selected Quarterly Data (unaudited)
Subsequent Events
Accounting Policies
Summary of Significant Accounting Policies (Policies)
Notes Tables
Summary of Significant Accounting Policies (Tables)
Marketable Securities (Tables)
Fair Value Measurements (Tables)
Property and Equipment (Tables)
Accrued expenses (Tables)
Stock Option Plans (Tables)
Restructuring Charges (Tables)
Income Taxes (Tables)
Commitments and Contingencies (Tables)
Net Loss Per Share Attributable to Common Stockholders (Tables)
Selected Quarterly Data (unaudited) (Tables)
Notes Details
Nature of Business and Basis of Presentation - Additional Information (Detail)
Summary of Significant Accounting Policies (Detail)
Summary of Significant Accounting Policies - Property and equipment (Detail)
Marketable Securities - Summary of Available-for-sale Securities Held (Detail)
Fair Value Measurements (Detail)
Fair Value Measurements - Narrative (Detail)
Property and Equipment (Detail)
Accrued Expenses (Detail)
Common Stock - Voting and Dividends (Detail)
Shareholders' Equity - Reverse Stock Split (Detail)
Common Stock - Offerings (Detail)
Stock Option Plans - Plan Information (Detail)
Stock Option Plans - Schedule of Stock Option Activity (Detail)
Stock Option Plans - Stock-Based Compensation Expense (Detail)
Stock option Plans - Fair value of stock options (Detail)
Restructuring Charges - Narrative (Detail)
Restructuring Charges - Schedule of Restructuring Charges (Detail)
Restructuring Charges - Accumulated Restructuring Charges (Detail)
Income Taxes - Effective Income Tax Rate and Deferred Tax Assets and Liabilities (Detail)
Income Taxes - Net Operating Loss Carryforwards (Detail)
Income Taxes - Tax Credits (Detail)
Income Taxes - Other (Detail)
Shared Services Agreement with Asuragen (Detail)
Retirement Plan (Detail)
License Agreements (Detail)
Commitments and Contingencies (Detail)
Net Loss Per Share Attributable to Common Stockholders - Computation (Detail)
Net Loss Per Share Attributable to Common Stockholders - Dilutive Securities (Detail)
Selected Quarterly Data (unaudited) (Detail)
Subsequent Events - Additional Information (Detail)
All Reports
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